Glucocorticoid-induced osteoporosis: considerations in ophthalmology.
نویسندگان
چکیده
Ophthalmologists, on occasion, take the initiative and the responsibility for prescribing systemic steroids to patients with vision-threatening ocular inflammatory disorders. Examples of such disorders include orbital pseudotumor, scleritis, uveitis, giant cell arteritis and optic neuritis. Preoccupation with the challenge and goal of preservation of vision, coupled with the propensity for some cases to relapse with attempted steroid taper (with resultant need to raise the steroid dose again) can lead to prolonged steroid use without attention to bone preservation strategies.
منابع مشابه
Expression of HCA2 Receptors in Femoral Epiphysis and Metaphysis of Rats with Dexamethasone-Induced Osteoporosis
The present study describes the changes in expression of hydroxy- carboxylic acid receptor 2 (HCA2 receptor) in femoral epiphysis and metaphysis of rats with glucocorticoid-induced osteoporosis (GIO). 16 growing male Sprauge dawley rats were randomly divided into two equal groups consisting of normal control and rats that were rendered osteoporotic by receiving 0.1 mg/kg/day dexamethasone throu...
متن کاملGlucocorticoid-induced osteoporosis.
Glucocorticoid-induced osteoporosis is one of the most important side-effects of glucocorticoid use, leading to an increased fracture risk. In this review, recent advances in the understanding of the mechanisms of glucocorticoid-induced osteoporosis are summarised. Methods to identify persons at risk for fractures are discussed, as well as the new ACR recommendations for the prevention and trea...
متن کاملGlucocorticoid induced osteoporosis.
Glucocorticoid therapy is the most common cause of secondary osteoporosis and the leading iatrogenic cause of the disease. Often, the presenting manifestation is fracture, which occurs in 30% to 50% of patients receiving long-term glucocorticoid therapy. Glucocorticoid-induced osteoporosis predominantly affects regions of the skeleton that have abundant cancellous bone such as lumbar spine and ...
متن کاملAdrenomedullin inhibits osteoclast differentiation through the suppression of receptor activator of nuclear factor-κB ligand-induced nuclear factor-κB activation in glucocorticoid-induced osteoporosis
The current study aimed to improve the understanding on the association between adrenomedullin and osteoporosis in mice with glucocorticoid-induced osteoporosis. Bone resorption and osteoporosis-associated indexes, including maximum load, stiffness, energy to failure, ultimate strength, elastic modulus, post-yield displacement and post-yield displacement, in mice with osteoporosis were analyzed...
متن کاملRecent Advances in the Management of Steroid Induced Osteoporosis
Correspondence to: Lai-Wa Kwok Abstract: Glucocorticoid-induced osteoporosis is the most common cause of drug-induced osteoporosis, leading to fragility fractures, decrease in mobility and quality of life. Patients who receive equivalent dose of prednisolone 5 mg for more than six months are at risk of glucocorticoid-induced osteoporosis, but there is no conclusive evidence for a safe cutoff fo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Ophthalmology
دوره 111 8 شماره
صفحات -
تاریخ انتشار 2004